DTWD1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006174
Fusion event
HBV-DTWD1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1375
Orient
-
Integrated sequence
GAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCAAAACTTATCGGGACTGACAACTCTGTTGTCCTCTCTCGGAAATACACCTCCTTCCCAT| |GGCTGCTCGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTT
Host Sequence
Chromosome
chr15
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
49938705/49646508 (Hg38)
End
49938705/49646508 (Hg38)
Orient
-
Location type
Intronic
Target gene
DTWD1
miRNAs that regulate target gene
hsa-mir-3163 ; hsa-mir-361-5p ; hsa-mir-374a-3p ; hsa-mir-4277 ; hsa-mir-4795-3p ; hsa-mir-5094 ; hsa-mir-513b-5p ; hsa-mir-584-3p
Nearest miRNA
hsa-mir-10393/Upstream/477355; hsa-mir-11181/Downstream/713821;
Nearest TSS
ENST00000557528/Upstream/25409; ENST00000560375/Downstream/230098;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/25223, chr15-CpG: 86/Downstream/535617
Upstream sequence
cacctcatatagtaacagattaccagcaggtttgtatgattcctctgcttgagatcaattagccatatgttcagaatccctggcctataacaacacttct
Downstream sequence
gtgctttaaaaaccccatgccacaatgactgttaaaagggctaggcgatgtagtctggtaggtttgtgaagttaactgtctgaaaaacttggatcaatgg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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