Basic Information
VIS ID
TVIS10006175
Fusion event
HBV-chr15 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
3130
Orient
+
Integrated sequence
GCATTCGGGCCAGGGTTCACCCCACCACACGGCGGTCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATATTGACAACAGTGCCAGCAGCGCCTCCTCCTG| |CCTCCACCAATCGGCAGTCAGGAAGACAGCCTACTCCCATCTCTCCACCTCTAAGAGACAGTCATCCTCAGGCCATGCAGTGGAA
Host Sequence
Chromosome
chr15
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
62627346/62335147 (Hg38)
End
62627346/62335147 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA15A
Nearest miRNA
hsa-mir-10393/Upstream/30413; hsa-mir-11181/Downstream/7882;
Nearest TSS
ENST00000557528/Upstream/50957; ENST00000561322/Downstream/53728;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/110541, chr15-CpG: 126/Downstream/55799
Nearby gene
MIR6085(+7882) ;
Upstream sequence
aaacggagtctctctctccatgccgcactgcctggagctggtggagatgtaacacaagcacccttgtggccaccaacactgggaccgcactgggtcagac
Downstream sequence
cagaagccagcacagcattgggtcttgcccaaggcctatggtgaccgctgcctggctatcaccaatgttttcaaggcccaagcgctcttcagtcagcagg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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