Basic Information
VIS ID
TVIS10006179
Fusion event
HBV-LOC105373693 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1353
Orient
+
Integrated sequence
TCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCAAAACTTATCGGGACTGACAACTCTGTTGTCCTCTCT| |CGGAAATACACCTCCTTCCCATGGCTGCTCGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGG
Host Sequence
Chromosome
chr2
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
155442668/154586156 (Hg38)
End
155442668/154586156 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC105373693
Nearest miRNA
hsa-mir-128-1/Upstream/3217745; hsa-mir-10b/Downstream/4600679;
Nearest TSS
ENST00000437798/Upstream/126299; ENST00000493505/Downstream/111661;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/712751, chr2-CpG: 141/Downstream/111337
Upstream sequence
gagatgtcctatacttgtgggttaaggttgggggatacaagagaaagatgcgaaggaggctttgggttgggaagaagggtggcaatgaaatgtggctgta
Downstream sequence
gtccaggaataatcagggaagcagataatttggttaaaatgtctcagcctaataagggaactgggcaggtggggataactaaaaaggagtgtataaaaga
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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