Basic Information
VIS ID
TVIS10006182
Fusion event
HBV-LOC105373938 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1732
Orient
+
Integrated sequence
AGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTG| |GGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCT
Host Sequence
Chromosome
chr2
Cytoband
q37.2
Reference genome
GRCh37/hg19
Start
235846926/234938282 (Hg38)
End
235846926/234938282 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105373938
Nearest miRNA
hsa-mir-10b/Upstream/2387709; hsa-mir-149/Downstream/2572649;
Nearest TSS
ENST00000437798/Upstream/255614; ENST00000484097/Downstream/13691;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/440385, chr2-CpG: 187/Downstream/13191
Upstream sequence
tggcgcaatctcagctcactgcaacctctgcctcctgggttcaagtgattcttcagccttagcctcccaagtagctgagattacaggcatgcgccaccac
Downstream sequence
gcctggctgatttttgtattttcagtagggacagggtttcaccatgttggccaagctggtctcgaactcctgacctcaagtgatccacccccgctcagcc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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