Basic Information
VIS ID
TVIS10006189
Fusion event
HBV-TENM3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2403
Orient
-
Integrated sequence
CAAATGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTC| |TCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTAC
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
183632727/182711574 (Hg38)
End
183632727/182711574 (Hg38)
Orient
+
Location type
Intron
Target gene
TENM3
miRNAs that regulate target gene
hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-let-7b-5p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-3679-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-2355-5p ; hsa-mir-3124-3p ; hsa-mir-4502 ; hsa-mir-138-2-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-338-3p ; hsa-mir-589-3p ; hsa-mir-2115-3p
Nearest miRNA
hsa-mir-12113/Upstream/542196; hsa-mir-3945/Downstream/2139439;
Nearest TSS
ENST00000502981/Upstream/3532; ENST00000508614/Downstream/62357;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/262268, chr4-CpG: 102/Downstream/87931
Upstream sequence
GTGTTTAATCTTTTCCTCACCTAAAATTTAAGCAAATGCTTTATTGGGGAAACACAGGCTAAAAGCATCAAAGTTATAAATAATTAAATCAATAAACAGC
Downstream sequence
CTCACTATTTGGATAAGATAGTTAAAGGTACTGTATACTCGCTCTTTGTTGACATATCTACATATATATCTCTATATAACTGTATATCACTAGGTTTGAC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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