Basic Information
VIS ID
TVIS10006194
Fusion event
HBV-chr6 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1717
Orient
+
Integrated sequence
CCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTG| |TTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGC
Host Sequence
Chromosome
chr6
Cytoband
q16.3
Reference genome
GRCh37/hg19
Start
103196125/102748250 (Hg38)
End
103196125/102748250 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/3623554; hsa-mir-1202/Downstream/4035875;
Nearest TSS
ENST00000381078/Upstream/820107; ENST00000635857/Downstream/1984120;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1345152, chr6-CpG: 79/Downstream/2110994
Upstream sequence
gtgatctcggctcactgcaagctctacctcccaggttcacgccattctgctgcctcagcctcccgagtatctgggaccgcaggtgcccgccaccacaccc
Downstream sequence
tagtatatacaaatataactaatatttggatatcgactttatgttttgtaaatttgctgtgctaccttaattaactttaatcatttgtcagtaggtcctt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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