SEMA3C _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006195
Fusion event
HBV-SEMA3C integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
3021
Orient
+
Integrated sequence
TCCCGATCACCAGTTGGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACCCCAACAAGGATCACTGGCCAGAGGCAAATCAGGTA| |GGAGCGGGAGCATTCGGGCCAGGGTTCACCCCACCACACGGCGGTCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATATTGACAACAGTGCCAGCAGCGC
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
80512240/80882924 (Hg38)
End
80512240/80882924 (Hg38)
Orient
-
Location type
Intron
Target gene
SEMA3C
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-375 ; hsa-mir-98-5p
Nearest miRNA
hsa-mir-10525/Upstream/4967655; hsa-mir-10399/Downstream/11321091;
Nearest TSS
ENST00000635602/Upstream/64515; ENST00000431501/Downstream/35505;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/747351, chr7-CpG: 59/Downstream/36066
Upstream sequence
cttgtagagtttctgccaagagatccactgttagtctgatgggtttccctttgtaggtaacctgacatttctctctgtctgcccttaacattttttcctt
Downstream sequence
TTACCTAAACCCTCTTATATaacaacaacaacaacaacaacaacaaACTAAAGGTAAATACACCTGAAAGATACAAAAGAGGATGCCATGAGATACACCT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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