Fusion event
HBV-SEMA3D integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATA| |AATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGG
End
84643973/85014657 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10525/Upstream/9099388; hsa-mir-10399/Downstream/7189358;
Upstream sequence
AGGAGCTCATGCTGTCATCCCCTCTGTGTCTCACCTACTTGTGCTGCAAGAGACCTGGATCCTGTTTATCTATCCACCCTCACCCCCACCCAAACAATTG
Downstream sequence
GTACAATCatatatatttatatattatttGCAAAACAGTGGGCATCAGTATATACATATTTAGAAATAAGAAATAAGGAAGGAACAATTATAAAAAAGGC
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).