Fusion event
HBV-FN1 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
CTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCC| |CTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGAAACTT
End
216285261/215420538 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10b/Upstream/1662379; hsa-mir-1244-1/Downstream/2479975;
Upstream sequence
CATTCAATTAAAATAAGCCTAAATTTGTCACCAAATTCAGCAAAAACCAGACGACTACCAATATCGAGATATTTTGGTCCAGTATTAGAGAGAAGACTTT
Downstream sequence
GCAAAGTTCTTTGCAAGCAACTGATCAAAGTCTGGAGCCAACTTCAGTCATGTGATTTCACATAGCTTTTCTTATCTGAAACTTGCTAACCATTCCCCCT
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).