Basic Information
VIS ID
TVIS10006244
Fusion event
HBV-chr2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1741
Orient
+
Integrated sequence
CCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTT| |GGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCA
Host Sequence
Chromosome
chr2
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
180923242/180058515 (Hg38)
End
180923242/180058515 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2G
Nearest miRNA
hsa-mir-10b/Upstream/197607; hsa-mir-1244-1/Downstream/1247078;
Nearest TSS
ENST00000437798/Upstream/51402; ENST00000629145/Downstream/633589;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/51368, chr2-CpG: 161/Downstream/921549
Junction sequence
A
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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