Fusion event
HBV-chr3 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
ACAGGAGGACATTATTAATAGATGTCAACAATATGTGGGCCCTCTTACAGTTAATGAAAAAAGGAGATTAAAATTAATTATGCCTGCTAGGTTCTATCCT| |AACCTTACCAAATATTTGCCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTC
End
152489066/152771277 (Hg38)
Nearest miRNA
hsa-let-7g/Upstream/1205282; hsa-mir-1224/Downstream/6511369;
Upstream sequence
TTTTTGTTCCCCATGAAGGCCACTCTAGCTACTGAGATTAAAAACAACATCCCTCTCTCCCCCCGCaaaaaaaaaaaaaaaaaaaaaaaaaaCTTTTTCT
Downstream sequence
TAAATAATTTTAATGGTACACATAACCAGTTACAAAGAGTGATGTCATACTTAGTATCAGGCCTTAATTGTGAAACATCAGAGATCTAAAGATTTTAATA
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).