Basic Information
VIS ID
TVIS10006250
Fusion event
HBV-chr3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
2657
Orient
-
Integrated sequence
ACAGGAGGACATTATTAATAGATGTCAACAATATGTGGGCCCTCTTACAGTTAATGAAAAAAGGAGATTAAAATTAATTATGCCTGCTAGGTTCTATCCT| |AACCTTACCAAATATTTGCCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTC
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
End
152489066/152771277 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-let-7g/Upstream/1205282; hsa-mir-1224/Downstream/6511369;
Upstream sequence
TTTTTGTTCCCCATGAAGGCCACTCTAGCTACTGAGATTAAAAACAACATCCCTCTCTCCCCCCGCaaaaaaaaaaaaaaaaaaaaaaaaaaCTTTTTCT
Downstream sequence
TAAATAATTTTAATGGTACACATAACCAGTTACAAAGAGTGATGTCATACTTAGTATCAGGCCTTAATTGTGAAACATCAGAGATCTAAAGATTTTAATA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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