Basic Information
VIS ID
TVIS10006255
Fusion event
HBV-chr4 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1822
Orient
+
Integrated sequence
TTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
104872523/103951366 (Hg38)
End
104872523/103951366 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/2620952; hsa-mir-1243/Downstream/5537332;
Nearest TSS
ENST00000502981/Upstream/231550; ENST00000510505/Downstream/10250;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/231726, chr4-CpG: 88/Downstream/1194673
Upstream sequence
acacacacacacaAatatatatgtgtgtgtgtatgtatgtgtatatataaatgtTTTTATTCCGTGTGTgtgtgtatgtgtgtgatattatctatggttt
Downstream sequence
ttatgcccagttttggggccagtttatggccagattttggaggcctgctcccaacactttccaaaatcatattataaattatgtctatttctaacctaag
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate