Basic Information
VIS ID
TVIS10006262
Fusion event
HBV-chr17 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1154
Orient
+
Integrated sequence
TGCCTTTATATGCATGTATACAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATATCTGCACCTTTACCCCGTTGC| |CCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACTGGATGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCT
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
14933983/15030666 (Hg38)
End
14933983/15030666 (Hg38)
Orient
-
Location type
Promoter
Fragile sites / regions
FRA17A
Nearest miRNA
hsa-mir-1253/Upstream/1487020; hsa-mir-10226/Downstream/220961;
Nearest TSS
ENST00000595228/Upstream/15861; ENST00000568256/Downstream/309;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/685262, chr17-CpG: 77/Downstream/229947
Nearby gene
CDRT7(+309) ;
Upstream sequence
AAACCACTTTAACTCTGTAAGTTATAAGTAAATTATATAtatatatatataatcactttaactctataagctataagtaactcatatgattctcataaca
Downstream sequence
accttagagaaaaatactatggtagtctccattttacagatgcaaaacctggggtgcagaTTTTAATCAacttgcccaaggtcccatagacaataactgc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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