Basic Information
VIS ID
TVIS10006264
Fusion event
HBV-chr5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1962
Orient
-
Integrated sequence
TTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTC| |TGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCA
Host Sequence
Chromosome
chr5
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
129990997/130655304 (Hg38)
End
129990997/130655304 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5C
Nearest miRNA
hsa-mir-10397/Upstream/1258157; hsa-mir-103a-1/Downstream/1562545;
Nearest TSS
ENST00000502646/Upstream/747217; ENST00000507584/Downstream/507323;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/749385, chr5-CpG: 27/Downstream/339774
Upstream sequence
aaaaagactgtccttgctatgcacactacagcaaaaactttgggactttgaaactggatttataatcccacaactgagaacagagtctctccaaactctt
Downstream sequence
CTGTGTATATCAAATATCTCAGACACAATGATCAACAGCAATTTCAGACACATGGACATATTAGGCATATGtttattttattagttatttttaaattgat
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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