Basic Information
VIS ID
TVIS10006270
Fusion event
HBV-LOC105373158 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1825
Orient
+
Integrated sequence
AGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAAT
Host Sequence
Chromosome
chr1
Cytoband
q42.13
Reference genome
GRCh37/hg19
Start
229196053/229060306 (Hg38)
End
229196053/229060306 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
LOC105373158
Nearest miRNA
hsa-mir-101-1/Upstream/598154; hsa-mir-1182/Downstream/1959522;
Nearest TSS
ENST00000473358/Upstream/22032; ENST00000323223/Downstream/34599;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/305102, chr1-CpG: 70/Downstream/210593
Upstream sequence
Ttagagttctaatttattaatagtttcctaagtgccaggcactggactaaatgtataatctccactttacagagacagaagcaaagatttgagatagcct
Downstream sequence
gtctaaaatctcactgtaagtggaagagctggagtttgaacccagataaacagaatgcacaggatgtgtgtgtgtctgtgtgtttgtgtgtgtgtgtatg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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