Basic Information
VIS ID
TVIS10006276
Fusion event
HBV-chr11 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
90
Orient
-
Integrated sequence
CTCCACAACATTCCACCAAGCTCTGCTAGATCCCAGAGTGAGGGGCCTATATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCC| |TGTTCCGACTACTGCCTCACCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACAGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTG
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
121559568/121688860 (Hg38)
End
121559568/121688860 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10392/Upstream/2375848; hsa-let-7a-2/Downstream/410897;
Nearest TSS
ENST00000527297/Upstream/60024; ENST00000526777/Downstream/427355;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/236267, chr11-CpG: 113/Downstream/966710
Upstream sequence
aaccattaatttcacctgtttccttttgctttgtgaatgtggctaatttgtgttaaatgtggaaaatgtttaacttacacgtgtggctcccatgaagttt
Downstream sequence
ctgttgaacagcattgATCTACATCAGTTTATTTTCTCTAAAATGCCAACGGCTTTTGTAATCCTACTACTATTTgaaagaccagggttcaactcctggt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate