Basic Information
VIS ID
TVIS10006279
Fusion event
HBV-chr12 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2833
Orient
-
Integrated sequence
AAACTAGGCATTATTTACATACTCTGTGGAAGGCTGGCATTCTATATAAGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGA| |ACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGGACGAATCTTTCTGTTCCCAATCCTCTGGGATTCTTTCCCGATCACCA
Host Sequence
Chromosome
chr12
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
47929676/47535893 (Hg38)
End
47929676/47535893 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA12A
Nearest miRNA
hsa-mir-1244-3/Upstream/171624; hsa-let-7i/Downstream/596904;
Nearest TSS
ENST00000382841/Upstream/120885; ENST00000621159/Downstream/128950;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/299996, chr12-CpG: 69/Downstream/169641
Upstream sequence
CCAAAAAAAGACAACATGGTCATAAAGGAGTCAAATTGTTAGTCTGTGCTCTCGACTTCTTTTTAAATATTAAGAGATTTTTACATACCAGATACTGCCT
Downstream sequence
CAGAAAATTCCAGTAAAGGGAGCTTAGAAGGGCTGGAGACAGGGACTAATGGGCACAGAGATGGAGGTGGCAGGAAAGAGAAATGCGGCCCTGGCAGTGC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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