Basic Information
VIS ID
TVIS10006287
Fusion event
HBV-LINC01543 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2886
Orient
-
Integrated sequence
GAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGG| |ACGAATCTTTCTGTTCCCAATCCTCTGGGATTCTTTCCCGATCACCAGTTGGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACC
Host Sequence
Chromosome
chr18
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
24011449/26431485 (Hg38)
End
24011449/26431485 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC01543
Nearest miRNA
hsa-mir-1-2/Upstream/2109739; hsa-mir-122/Downstream/159982;
Nearest TSS
ENST00000575820/Upstream/8490; ENST00000583852/Downstream/29391;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/204356, chr18-CpG: 348/Downstream/115331
Upstream sequence
atacctgtgtgccatttgtatgtcttcttttgagaaatgtctattcaaaccttttgcccattttaaaatcagattattagattttttcctattgagttgt
Downstream sequence
ttgagctccttatatattctggttattaatctcttgtcagatgggtagtctgcaaatattttctctcattctgtgggctgtctcttcacttcgttgattg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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