FBLN7 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006289
Fusion event
HBV-FBLN7 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2640
Orient
-
Integrated sequence
TTTCCTAACATTCATTTACAGGAGGACATTATTAATAGATGTCAACAATATGTGGGCCCTCTTACAGTTAATGAAAAAAGGAGATTAAAATTAATTATGC| |CTGCTAGGTTCTATCCTAACCTTACCAAATATTTGCCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAG
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
112948274/112190697 (Hg38)
End
112948274/112190697 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2B
Target gene
FBLN7
miRNAs that regulate target gene
hsa-mir-377-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/419563; hsa-mir-10b/Downstream/1392262;
Nearest TSS
ENST00000437798/Upstream/8814; ENST00000476511/Downstream/41188;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/3252, chr2-CpG: 67/Downstream/63834
Upstream sequence
attaatagtaattacagctactgtctttgtttttgctcaaattgttctatctttggttcttgggagctgcttcgaggtggctgattccttttgacatgac
Downstream sequence
cctagtagtctttttcatcctgtatattttctgcccctgccctgaaatcagctgttttctcccagtaatccctggttccttctagtgggggatggtaatt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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