Basic Information
VIS ID
TVIS10006296
Fusion event
HBV-chr20 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1788
Orient
+
Integrated sequence
ACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGC| |ATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG
Host Sequence
Chromosome
chr20
Cytoband
q12
Reference genome
GRCh37/hg19
Start
39219761/40591121 (Hg38)
End
39219761/40591121 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC102724968 ; LOC107985435
Nearest miRNA
hsa-mir-103a-2/Upstream/2074489; hsa-mir-1-1/Downstream/577902;
Nearest TSS
ENST00000382410/Upstream/470080; ENST00000361337/Downstream/98119;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/1540663, chr20-CpG: 92/Downstream/91617
Upstream sequence
aacataaaatacctgtgtgtgtgacatatatATGAatatatatgtcttgtatatttgttctgtttctctggagaatcctaataAcatctctttgtgtact
Downstream sequence
ttattttcacatatactgattctggctagttttatatgccccactatgagaaaaaagtatcaatgctatatttactcatgatgccatggcacttcagaac
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate