PROS1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006300
Fusion event
HBV-PROS1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1820
Orient
+
Integrated sequence
GTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAA
Host Sequence
Chromosome
chr3
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
93691259/93972415 (Hg38)
End
93691259/93972415 (Hg38)
Orient
-
Location type
Intron
Target gene
PROS1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-494-3p
Nearest miRNA
hsa-let-7g/Upstream/6746138; hsa-mir-12124/Downstream/2387549;
Nearest TSS
ENST00000440867/Upstream/13661; ENST00000478400/Downstream/1224;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/4857458, chr3-CpG: 39/Downstream/1295
Upstream sequence
AGTAACAGCCCCAAGGGAACTAAACAACACCATCATTCATAAAATGTTGTGAATCTGTTACGAGCTAATTTGAAATACGGAGCCTAAGGTGTTTTTGGTa
Downstream sequence
ATTGATATATAATTTTCTAGAAATTTCCATCTTCAAAAAGTTTACTTTGGAGCTCTAGACTCCTAAAAGTTATTTGTAATTCAGAGTTCTCACTCCTGTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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