Basic Information
VIS ID
TVIS10006301
Fusion event
HBV-chr4 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1790
Orient
+
Integrated sequence
CGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCAT| |AAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTG
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
35472208/35470586 (Hg38)
End
35472208/35470586 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/6650918; hsa-mir-1243/Downstream/955780;
Nearest TSS
ENST00000502981/Upstream/801820; ENST00000502245/Downstream/575448;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/4747366, chr4-CpG: 100/Downstream/773423
Upstream sequence
GCTGCAATACTCAATGCCAAGACTGCATGTGTGTGAGCAGCTACCACCTGGGTTTTTGGTGGCATCCAGTCATGGTCTTTCTAAGGCCTCTTTGAACTCT
Downstream sequence
TATCTCACCTACCTATTGCATATCTAAACTGAAGTGCTTAGCAGCCAAGCACTGTATCCTCTCTCTACACCCATTCTTTGCAATACAAATTGAAGGATTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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