INPP4B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006302
Fusion event
HBV-INPP4B integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2049
Orient
-
Integrated sequence
CTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACC| |TCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAA
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
143418774/142497621 (Hg38)
End
143418774/142497621 (Hg38)
Orient
+
Location type
Intron
Target gene
INPP4B
miRNAs that regulate target gene
hsa-mir-222-3p ; hsa-mir-181a-5p ; hsa-mir-765
Nearest miRNA
hsa-mir-12113/Upstream/16990314; hsa-mir-1305/Downstream/845839;
Nearest TSS
ENST00000502981/Upstream/23213; ENST00000514766/Downstream/16660;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/860451, chr4-CpG: 111/Downstream/348166
Nearest cancer related gene
INPP4B(TSG, No orient, 0)
Upstream sequence
GCTGCAATACTCAATGCCAAGACTGCATGTGTGTGAGCAGCTACCACCTGGGTTTTTGGTGGCATCCAGTCATGGTCTTTCTAAGGCCTCTTTGAACTCT
Downstream sequence
AGTACACTTAAACATAAGTAAAACTATGTCTAAATTATTGGTTTGATTTTAATTTCATTGACTTTTTCAAAATTATCCTAAAACAACAATATTTCCCAGT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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