Basic Information
VIS ID
TVIS10006304
Fusion event
HBV-chr4 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1816
Orient
+
Integrated sequence
GTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGT
Host Sequence
Chromosome
chr4
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
180475271/179554118 (Hg38)
End
180475271/179554118 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/5130254; hsa-mir-1305/Downstream/2615175;
Nearest TSS
ENST00000502981/Upstream/88813; ENST00000512480/Downstream/1204920;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2111564, chr4-CpG: 160/Downstream/503767
Upstream sequence
AGGAAGAAGAAAGGATATCATTCTGACCAGAGGGGTGAAAAACAACCTGCATCTGATCCTGAGGCATAATACTATTAACACAATTCTTTTATGTTTCAGT
Downstream sequence
atctctcttgcttttccccacaCCAGGTCACCTACTATTTATCACCGGATGGTTTTTAATACCTATCAATGACTTAGAGATGTTTTTCCCTCTAATTTCA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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