Basic Information
VIS ID
TVIS10006309
Fusion event
HBV-chr5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1347
Orient
-
Integrated sequence
TGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCAAAACTTATCGGGACTGACAACTCTGTTGTC| |CTCTCTCGGAAATACACCTCCTTCCCATGGCTGCTCGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATC
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
165908843/166481838 (Hg38)
End
165908843/166481838 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/5996388; hsa-mir-103a-1/Downstream/1684007;
Nearest TSS
ENST00000502646/Upstream/353340; ENST00000517586/Downstream/444532;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2975898, chr5-CpG: 17/Downstream/496641
Upstream sequence
GCCGCGCTTCCCCGCCCGCGCGCCGCTCGCGCTCCCAGGGTGCAGGGACGCCAGCGAGGGCCCCAGCGGAGAGAGGTCGAATCGGCCTAGGCTGTGGGGT
Downstream sequence
tgaaattttgacagaactgcatttgagttctagcttcatcattacttatctgtgagatggacaattgacttcacctctctgaccctcagtttcttatcta
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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