Basic Information
VIS ID
TVIS10006325
Fusion event
HBV-LOC105374313 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1778
Integrated sequence
CGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGC| |AGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACC
Host Sequence
Chromosome
chr3
Cytoband
q25.1
Reference genome
GRCh38
Start
150124112 (Hg38)
End
150124112 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
LOC105374313
Nearest miRNA
hsa-let-7g/Upstream/15686206; hsa-mir-1224/Downstream/1441764;
Nearest TSS
ENST00000440867/Upstream/26080; ENST00000472890/Downstream/101078;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/73230, chr3-CpG: 17/Downstream/57196
Nearby gene
TMEM183B(-140746) ; LINC01213(+114406) ;
Upstream sequence
GCCAGCAGGAGCTTTGCT
Junction sequence
GCCAGCAGGAGCTTTGCTCTAGGACAAAGACCTTTAAT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate