Basic Information
VIS ID
TVIS10006326
Fusion event
HBV-ADGRG6 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1805
Integrated sequence
TCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGC| |AGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGA
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh38
Start
142418190 (Hg38)
End
142418190 (Hg38)
Location type
Intron
Target gene
ADGRG6
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-99a-5p
Nearest miRNA
hsa-mir-10398/Upstream/1734307; hsa-mir-1202/Downstream/8684485;
Nearest TSS
ENST00000381078/Upstream/1081; ENST00000497898/Downstream/19854;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/115874, chr6-CpG: 60/Downstream/508482
Upstream sequence
TAATCCCAGCTACTACTC
Junction sequence
TAATCCCAGCTACTACTCACGCAGACCAATTTATGCCTA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate