Basic Information
VIS ID
TVIS10006328
Fusion event
HBV-chr12 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1828
Integrated sequence
CGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTT| |GCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGA
Host Sequence
Chromosome
chr12
Cytoband
q23.2
Reference genome
GRCh38
Start
102998812 (Hg38)
End
102998812 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/2808863; hsa-mir-1178/Downstream/931613;
Nearest TSS
ENST00000382841/Upstream/40402; ENST00000552759/Downstream/153030;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/32961, chr12-CpG: 29/Downstream/303500
Nearby gene
ASCL1(-38296) ; C12orf42(+238778) ;
Nearest cancer related gene
ASCL1(OG, -38296) ;
Upstream sequence
AAAATGTAACAAGAGTC
Junction sequence
AAAATGTAACAAGAGTCGAAAAAGTTGCATGGTGCTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate