Basic Information
VIS ID
TVIS10006331
Fusion event
HBV-chr15 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1754
Integrated sequence
GGTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGG| |ACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAG
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh38
Start
44884789 (Hg38)
End
44884789 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/166896; hsa-mir-11181/Downstream/548261;
Nearest TSS
ENST00000557528/Upstream/58249; ENST00000557864/Downstream/71913;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/172642, chr15-CpG: 29/Downstream/138214
Nearby gene
TRIM69(-117017) ; TERB2(+71903) ;
Downstream sequence
AAAAAAGGAAAAAAAAACTCATTTGGAGT
Junction sequence
AGGAGTTGGGGGAGGAGAAAAAAAGGAAAAAAAAACTCATTTGGAGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate