Basic Information
VIS ID
TVIS10006339
Fusion event
HBV-chr4 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
2060
Integrated sequence
GCCCATGACCAAGCCCCAGCCAGTGGGGGTTGCGTCAGCAAACACTTGGCACAGACCTGGCCGTTGCCGGGCAACGGGGTAAAGGTTCAGGTATTGTTTA| |CACAGAAAGGCCTTGTAAGTTGGCGAGAAAGTGAAAGCCTGCTTAGATTGAATACATGCATACAAAGGCATCAACGCAGGATAACCACATTGTGTAAAAG
Host Sequence
Chromosome
chr4
Cytoband
q34.2
Reference genome
GRCh38
Start
176197346 (Hg38)
End
176197346 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1773482; hsa-mir-1305/Downstream/5971947;
Nearest TSS
ENST00000502981/Upstream/1675; ENST00000513139/Downstream/40228;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1604, chr4-CpG: 111/Downstream/122438
Nearby gene
SPATA4(-1675) ; ASB5(+16328) ;
Nearest cancer related gene
SPATA4(OG, -1675) ;
Upstream sequence
TAAAGGGAAAAGTCAAAGTG
Junction sequence
TAAAGGGAAAAGTCAAAGTGAAGTATGGTGAGGTAACAATGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate