Basic Information
VIS ID
TVIS10006348
Fusion event
HBV-LOC101928978 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1792
Integrated sequence
GGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGC| |AGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAA
Host Sequence
Chromosome
chr4
Cytoband
q21.23
Reference genome
GRCh38
Start
84240667 (Hg38)
End
84240667 (Hg38)
Location type
Intron
Target gene
LOC101928978
Nearest miRNA
hsa-mir-12113/Upstream/1487237; hsa-mir-1243/Downstream/1481801;
Nearest TSS
ENST00000502981/Upstream/508912; ENST00000511298/Downstream/139522;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/703960, chr4-CpG: 39/Downstream/240944
Downstream sequence
CCAAACATATTAATTGGGAT
Junction sequence
GTACTAGGAGGCTGTAGGCATCCCAAACATATTAATTGGGAT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate