Basic Information
VIS ID
TVIS10006352
Fusion event
HBV-chr4 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1832
Integrated sequence
CGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGG| |GATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGAGGAG
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh38
Start
58975164 (Hg38)
End
58975164 (Hg38)
Fragile sites / regions
FRA4B
Nearest miRNA
hsa-mir-12113/Upstream/6262417; hsa-mir-1243/Downstream/1947455;
Nearest TSS
ENST00000502981/Upstream/410042; ENST00000513836/Downstream/1933;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1779215, chr4-CpG: 222/Downstream/2225001
Nearby gene
LOC105377246(+907) ;
Downstream sequence
CACTATTGATAATGTCAA
Junction sequence
ACATGAGATGATTAGGCAGACACTATTGATAATGTCAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate