Basic Information
VIS ID
TVIS10006363
Fusion event
HBV-chr6 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1840
Integrated sequence
TCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGAC| |AACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGAGGAGCCGAAAAG
Host Sequence
Chromosome
chr6
Cytoband
q23.2
Reference genome
GRCh38
Start
132078040 (Hg38)
End
132078040 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/285809; hsa-mir-1202/Downstream/37152;
Nearest TSS
ENST00000381078/Upstream/126667; ENST00000440246/Downstream/7044;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/126614, chr6-CpG: 84/Downstream/322914
Nearby gene
CCN2(-126868) ; MIR548AJ1(+37151) ;
Nearest cancer related gene
CCN2(TSG, -126868) ;
Downstream sequence
CCTCAACCCAAGACCC
Junction sequence
ACTTTTTCNCCTCTGCCTAACCTCAACCCAAGACCC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate