Basic Information
VIS ID
TVIS10006364
Fusion event
HBV-chr11 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1810
Integrated sequence
AGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCA| |TGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCC
Host Sequence
Chromosome
chr11
Cytoband
q24.3
Reference genome
GRCh38
Start
128419044 (Hg38)
End
128419044 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7a-2/Upstream/1430502; hsa-mir-4697/Downstream/103346;
Nearest TSS
ENST00000527297/Upstream/207607; ENST00000525706/Downstream/44906;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1415130, chr11-CpG: 20/Downstream/32722
Nearby gene
ETS1(+39716) ;
Nearest cancer related gene
ETS1(OG, +39716) ;
Downstream sequence
AGTGTATCAGGTAT
Junction sequence
NTAAATTGGTGTGTTCACCAAGTGTATCAGGTAT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate