Basic Information
VIS ID
TVIS10006366
Fusion event
HBV-chr10 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1813
Integrated sequence
GACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGG| |AAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCA
Host Sequence
Chromosome
chr10
Cytoband
q25.3
Reference genome
GRCh38
Start
114424498 (Hg38)
End
114424498 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/250319; hsa-mir-202/Downstream/2402990;
Nearest TSS
ENST00000439456/Upstream/19742; ENST00000436932/Downstream/16543;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/19658, chr10-CpG: 46/Downstream/207209
Nearby gene
AFAP1L2(-19720) ; ABLIM1(+6611) ;
Nearest cancer related gene
AFAP1L2(TSG, -19720) ;
Upstream sequence
TGAGCGTAAAGCTTAGT
Junction sequence
TGAGCGTAAAGCTTAGTTGCTGGAGAACACACCAATT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate