Basic Information
VIS ID
TVIS10006369
Fusion event
HBV-chr13 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1807
Integrated sequence
CCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAG| |CCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGT
Host Sequence
Chromosome
chr13
Cytoband
q21.1
Reference genome
GRCh38
Start
58018244 (Hg38)
End
58018244 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA13B ; FRA13C
Nearest miRNA
hsa-mir-1297/Upstream/2843696; hsa-mir-1267/Downstream/3181554;
Nearest TSS
ENST00000623511/Upstream/383231; ENST00000615202/Downstream/147583;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/383448, chr13-CpG: 52/Downstream/2145282
Nearby gene
PCDH17(-289313) ; LINC02338(+147582) ;
Nearest cancer related gene
PCDH17(TSG, -289313) ;
Downstream sequence
TGGTGACACATACCTGTAGT
Junction sequence
GGCATAAATTGGTGTGTTCATGGTGACACATACCTGTAGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate