Basic Information
VIS ID
TVIS10006371
Fusion event
HBV-chrX integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
2870
Integrated sequence
AGGATGAAGAGGAAGATGATAAAACGCCGCAGACACATCCAGCGATAACCAGGACAAGTTGGAGGACAAGAGGTTGGTGAGTGATTGGAGGTTGGGGACT| |GCGAATTTTGGCCAAGACACACGGTAGTTCCCCCTAGAAAATTGAGAGAAGTCCACCACGAGTCTAGACTCTGCGGTATTGTGAGGATTCTTGTCAACAA
Host Sequence
Chromosome
chrX
Cytoband
p11.3
Reference genome
GRCh38
Start
47283158 (Hg38)
End
47283158 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1587/Upstream/1536034; hsa-let-7f-2/Downstream/304271;
Nearest TSS
ENST00000429181/Upstream/36076; ENST00000366224/Downstream/14694;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/49251, chrX-CpG: 73/Downstream/199330
Nearby gene
USP11(-34830) ; ZNF157(+87441) ;
Downstream sequence
TTTCTGCACATTTGTGTCA
Junction sequence
ATGGGAGGTTGGNCNTCCNATTTCTGCACATTTGTGTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate