Basic Information
VIS ID
TVIS10006375
Fusion event
HBV-MROH2A integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1784
Integrated sequence
ACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATC| |CAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGC
Host Sequence
Chromosome
chr2
Cytoband
q37.1
Reference genome
GRCh38
Start
233776390 (Hg38)
End
233776390 (Hg38)
Location type
Intron
Target gene
MROH2A
Nearest miRNA
hsa-mir-10b/Upstream/1225817; hsa-mir-149/Downstream/3734541;
Nearest TSS
ENST00000437798/Upstream/666; ENST00000480634/Downstream/1940;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/20965, chr2-CpG: 88/Downstream/77460
Downstream sequence
CTGTTGCCCAGGCTGGA
Junction sequence
GGTCTTTGTACTAGGAGGCTCTGTTGCCCAGGCTGGA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate