Basic Information
VIS ID
TVIS10006376
Fusion event
HBV-NYAP2 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1820
Integrated sequence
AGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGAT| |GTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGA
Host Sequence
Chromosome
chr2
Cytoband
q36.3
Reference genome
GRCh38
Start
225661861 (Hg38)
End
225661861 (Hg38)
Location type
Intronic
Target gene
NYAP2
miRNAs that regulate target gene
hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-382-5p ; hsa-mir-495-5p ; hsa-mir-4799-5p ; hsa-mir-4780 ; hsa-mir-5579-5p ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-4694-3p ; hsa-mir-4695-3p ; hsa-mir-2276-3p ; hsa-mir-6787-3p ; hsa-mir-1304-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-6736-3p ; hsa-mir-6890-3p ; hsa-mir-1306-5p
Nearest miRNA
hsa-mir-10b/Upstream/651321; hsa-mir-1244-1/Downstream/996849;
Nearest TSS
ENST00000437798/Upstream/260975; ENST00000609089/Downstream/36653;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/78846, chr2-CpG: 74/Downstream/1129326
Nearby gene
NYAP2(-7843) ; LOC646736(+480932) ;
Downstream sequence
TTACAGACATGCACCAC
Junction sequence
CTGCGCACCAGCACCATGCATTACAGACATGCACCAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate