Basic Information
VIS ID
TVIS10006378
Fusion event
HBV-chr12 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1827
Integrated sequence
TCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATT| |TGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAG
Host Sequence
Chromosome
chr12
Cytoband
q24.23
Reference genome
GRCh38
Start
119899421 (Hg38)
End
119899421 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA12E ; FRA12C
Nearest miRNA
hsa-let-7i/Upstream/185697; hsa-mir-3612/Downstream/256013;
Nearest TSS
ENST00000382841/Upstream/22130; ENST00000546861/Downstream/90448;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/22056, chr12-CpG: 189/Downstream/89322
Nearby gene
CIT(-22130) ; BICDL1(+90422) ;
Upstream sequence
TTATAGCCCTACTAGAGTTG
Junction sequence
TTATAGCCCTACTAGAGTTGGAAAAAGTTGCATGGTGCTGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate