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VISDB
Viral Integration Site DataBase
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TVIS10006379
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006379
Fusion event
HBV-GRIK2 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1829
Integrated sequence
GTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTG| |CGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGAG
Host Sequence
Chromosome
chr6
Cytoband
q16.3
Reference genome
GRCh38
Start
101585725 (Hg38)
End
101585725 (Hg38)
Location type
Intron
Target gene
GRIK2
miRNAs that regulate target gene
hsa-mir-26b-5p
;
hsa-mir-1303
;
hsa-mir-3122
;
hsa-mir-3123
;
hsa-mir-3201
;
hsa-mir-3675-5p
;
hsa-mir-3913-5p
;
hsa-mir-3925-5p
;
hsa-mir-450a-1-3p
;
hsa-mir-450b-3p
;
hsa-mir-4791
;
hsa-mir-5002-5p
;
hsa-mir-5089-5p
;
hsa-mir-6513-5p
;
hsa-mir-6728-5p
;
hsa-mir-6751-5p
;
hsa-mir-6752-5p
;
hsa-mir-6803-5p
;
hsa-mir-6835-5p
;
hsa-mir-6842-5p
;
hsa-mir-6890-5p
;
hsa-mir-7110-5p
;
hsa-mir-769-3p
;
hsa-mir-887-5p
Nearest miRNA
hsa-mir-10398/Upstream/2461029; hsa-mir-1202/Downstream/5198400;
Nearest TSS
ENST00000381078/Upstream/186932;
ENST00000455610/Downstream/36223;
Nearest CpG islands
None/Target,
chr6-CpG: 120/Upstream/182627
,
chr6-CpG: 79/Downstream/3273519
Upstream sequence
GGAAAAAGGTGACACAT
Junction sequence
GGAAAAAGGTGACACATTTGAAAAAGTTGCATGGNGCT
* Color:
Human Sequence
/
Virus Sequence
/
Overlapped sequence
/
Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Sample Information
×
Sample name
4
Sample type
Tumor
Age
18
Gender
Female
CpG Island Information
×
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