Basic Information
VIS ID
TVIS10006387
Fusion event
HBV-chr10 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1828
Integrated sequence
CGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTT| |GCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGA
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh38
Start
53190646 (Hg38)
End
53190646 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA10C
Nearest miRNA
hsa-mir-1265/Upstream/1890991; hsa-mir-107/Downstream/1417228;
Nearest TSS
ENST00000439456/Upstream/214831; ENST00000422842/Downstream/120419;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/318980, chr10-CpG: 36/Downstream/2437662
Nearby gene
MBL2(-418946) ; PCDH15(+612124) ;
Upstream sequence
TTTCAAAAAATTAATTTTTA
Junction sequence
TTTCAAAAAATTAATTTTTAGAAAAAGTTGCANGGNNNGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate