Basic Information
VIS ID
TVIS10006388
Fusion event
HBV-LOC105378712 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1805
Integrated sequence
TCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGC| |AGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGA
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh38
Start
50290811 (Hg38)
End
50290811 (Hg38)
Location type
Intronic
Target gene
LOC105378712
Nearest miRNA
hsa-mir-12136/Upstream/5745259; hsa-mir-101-1/Downstream/769026;
Nearest TSS
ENST00000473358/Upstream/10636; ENST00000424664/Downstream/4735;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/242163, chr1-CpG: 86/Downstream/42184
Nearby gene
ELAVL4(-87026) ; DMRTA2(+127853) ;
Upstream sequence
AACATGCCCCATACCTGC
Junction sequence
AACATGCCCCATACCTGCnnGCAGNCCAATTTATGCCTAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate