Basic Information
VIS ID
TVIS10006394
Fusion event
HBV-KRTAP7-1 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1726
Integrated sequence
GCACAGACGGGGAGTCCGCGTAAAGAGAGGTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGG| |GTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATAT
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh38
Start
30829731 (Hg38)
End
30829731 (Hg38)
Location type
at beginning of exon
Target gene
KRTAP7-1
Nearest miRNA
hsa-let-7c/Upstream/454353; hsa-mir-3197/Downstream/2720931;
Nearest TSS
ENST00000624081/Upstream/16479; ENST00000433071/Downstream/28;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/889943, chr21-CpG: 24/Downstream/422097
Downstream sequence
TGTGAAGGGTAAGTTACCCA
Junction sequence
CTTCNAAGACTGTTTGTTTTGTGAAGGGTAAGTTACCCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate