Basic Information
VIS ID
TVIS10006401
Fusion event
HBV-chr16 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1815
Integrated sequence
CCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAA| |ACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGT
Host Sequence
Chromosome
chr16
Cytoband
p13.12
Reference genome
GRCh38
Start
12584020 (Hg38)
End
12584020 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/1277493; hsa-mir-11401/Downstream/136301;
Nearest TSS
ENST00000527434/Upstream/26326; ENST00000615100/Downstream/27024;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/15200, chr16-CpG: 41/Downstream/219488
Nearby gene
SNX29(-9731) ; CPPED1(+75778) ;
Downstream sequence
nCTAAGTGTCCCTCCTGTGGT
Junction sequence
TTGGTCTGCGCACCAGCACCnCTAAGTGTCCCTCCTGTGGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate