Basic Information
VIS ID
TVIS10006403
Fusion event
HBV-chr10 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1972
Integrated sequence
CAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGAGGAGCCGAAAAGGTTCCACGCATGCGCTGATGGCCCATGACCAA| |GCCCCAGCCAGTGGGGGTTGCGTCAGCAAACACTTGGCACAGACCTGGCCGTTGCCGGGCAACGGGGTAAAGGTTCAGGTATTGTTTACACAGAAAGGCC
Host Sequence
Chromosome
chr10
Cytoband
p14
Reference genome
GRCh38
Start
11454352 (Hg38)
End
11454352 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-3155a/Upstream/5302075; hsa-mir-107/Downstream/676408;
Nearest TSS
ENST00000439456/Upstream/134468; ENST00000604634/Downstream/77923;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/109476, chr10-CpG: 41/Downstream/8871
Nearby gene
CELF2(-117679) ; USP6NL(+6157) ;
Downstream sequence
CCAGGCCTCCCTCACTG
Junction sequence
GTTTTTGCCTTCTGACTTCTCCAGGCCTCCCTCACTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate