Basic Information
VIS ID
TVIS10006407
Fusion event
HBV-chr3 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1727
Integrated sequence
CACAGACGGGGAGTCCGCGTAAAGAGAGGTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGG| |TCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATT
Host Sequence
Chromosome
chr3
Cytoband
q26.31
Reference genome
GRCh38
Start
172866200 (Hg38)
End
172866200 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/1759441; hsa-mir-1224/Downstream/2503340;
Nearest TSS
ENST00000440867/Upstream/47869; ENST00000447709/Downstream/275068;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/115145, chr3-CpG: 49/Downstream/529280
Nearby gene
ECT2(-44726) ; SPATA16(+23156) ;
Nearest cancer related gene
ECT2(OG, -44726) ;
Upstream sequence
GCTTTTATAGTTGAGGCC
Junction sequence
GCTTTTATAGTTGAGGCCTAAACAAACNGTCTTTGAAG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate