Basic Information
VIS ID
TVIS10006411
Fusion event
HBV-chr6 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1826
Integrated sequence
GTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATAT| |TTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCA
Host Sequence
Chromosome
chr6
Cytoband
q15
Reference genome
GRCh38
Start
91787314 (Hg38)
End
91787314 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA6G
Nearest miRNA
hsa-mir-10398/Upstream/265577; hsa-mir-1202/Downstream/6237217;
Nearest TSS
ENST00000381078/Upstream/96886; ENST00000452624/Downstream/601513;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1175814, chr6-CpG: 92/Downstream/1629240
Nearby gene
CASC6(-96886) ;
Upstream sequence
GTAGAAAACAATAGGATTT
Junction sequence
GTAGAAAACAATAGGATTTAAAAGTTGCANGGTGCNGGN
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate