PDE8A _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006413
Fusion event
HBV-PDE8A integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1825
Integrated sequence
GGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATA| |TTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGC
Host Sequence
Chromosome
chr15
Cytoband
q25.3
Reference genome
GRCh38
Start
85124435 (Hg38)
End
85124435 (Hg38)
Location type
Intron
Target gene
PDE8A
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-mir-33a-5p
Nearest miRNA
hsa-mir-10393/Upstream/2057020; hsa-mir-11181/Downstream/256161;
Nearest TSS
ENST00000557528/Upstream/4244; ENST00000560571/Downstream/256136;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/141801, chr15-CpG: 115/Downstream/109458
Downstream sequence
CCACCCTCCTCCCCAGCTC
Junction sequence
CACCANCACCATGCAACTTTCCACCCTCCTCCCCAGCTC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate