MAPK4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006416
Fusion event
HBV-MAPK4 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1817
Integrated sequence
CCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAAC| |GATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTAT
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh38
Start
50627176 (Hg38)
End
50627176 (Hg38)
Location type
Intron
Target gene
MAPK4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-127-3p
Nearest miRNA
hsa-mir-1-2/Upstream/500613; hsa-mir-122/Downstream/2609925;
Nearest TSS
ENST00000575820/Upstream/66534; ENST00000586735/Downstream/2242;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/65957, chr18-CpG: 21/Downstream/36888
Downstream sequence
TTGGACCAGCCTTGGGGAATGG
Junction sequence
GGTCTGCNCACCAGCACCATTTGGACCAGCCTTGGGGAATGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate